Trait Analysis · Existing single-annotation S-LDSC heritability results, grouped by UK Biobank, FinnGen and the Million Veteran Program. Search original phenotype names and inspect each study separately.
Trait Analysis works independently. To select one GWAS study and explore its associated regions, open the Guided Workflow. Its P-value threshold and region selection do not change these existing S-LDSC results.
Reading these numbers
The model is LD score regression with the Evo2 score as the single continuous annotation (1000G EUR, MAF ≥ 5% reference). No baseline-LD annotations are included, so the coefficient measures the annotation's association with per-SNP heritability on its own — not its contribution over and above conservation, coding status and the other baseline-LD properties. The interpretation depends on the selected annotation: signed Δ describes a likelihood-shift direction, while |Δ| describes its magnitude. These results do not establish added information beyond conservation.
The coefficient is per unit of the annotation, so its absolute size carries no meaning on its own; it is given with its standard error and 95% confidence interval, and the z-score is the quantity to compare. Because the scale is not comparable across annotations or cohorts, the rank and percentile within each biobank are shown alongside.
h² is the trait's total observed-scale SNP heritability from the same run: a large z on a trait with h² near zero is partitioning almost nothing. The LDSC intercept helps assess inflation beyond that attributed to polygenic signal; interpret it alongside the study's design and quality-control information.
Each biobank is ranked only against its own traits — the three sets differ in phenotype definition, ancestry and sample size, so z-scores are compared as ranks across biobanks, never pooled. Search matches are candidate phenotype records, not verified matches of the same study or evidence of replication. A search with no matches does not establish that the phenotype has no stored result under another original name.
Source details
Analysis: Evo2VED single-annotation S-LDSC of UKB, FinnGen and MVP studies.
Source table: gwas_ldsc.json; result release:
2026-07-24-annotation-fix+ldsc-raw-abs. Original trait IDs, source biobank,
annotation and available sample sizes are retained in the tables and exports. A result-release
label is separate from the original cohort's data release; study releases not supplied here
remain unverified.