Evo2 Variant Effect Database

Update history

Website releases describe changes to browsing, annotations and analysis interfaces. Each source keeps its own release and sample definition; a website update does not imply that Evo2 scores were recomputed.

Website v1.2 · 24 September 2026

  • Corrected cross-biobank trait selection so the clicked phenotype, detail view and exported result remain aligned.
  • Restored complete GTEx model pagination, filtered results, exports and exact-allele evidence using verified local archives.
  • Accelerated source directories and SCREEN interval summaries; added bounded waiting, recovery messages and retry controls.
  • Clarified the distinct counts for scored alleles in a window, plotted alleles and stored GWAS records, including export metadata.

Website v1.1 · 16 September 2026

  • Aligned the default configuration with the manuscript's main case studies: 40B avgRC. All six configurations and explicitly selected model links remain available.
  • Corrected the scoring diagram to a 2-kb context, clarified substitutions and indels, and replaced illustrative likelihood values with the stored rs429358 example.
  • Added SCREEN Registry V4 GRCh38 class, element-accession and overlap-count fields to the variant table, with separate field definitions and annotation details in variant reports.
  • Integrated the audited 12 September eQTLGen package: original blood cis-eQTL associations and frozen gene models, with source allele direction, sample membership and analysis branches preserved.
  • Updated the hypertension and depression examples, the Evo 2 Nature citation, and source references accompanying the frozen model-comparison figures.
  • Improved guided study selection, gene-window browsing, ancestry-frequency bars and bounded tables; added the shared site navigation to the table and SQL pages.
  • Changed evidence and molecular-result browsing to source selection before querying. Fixed analysis requests and downloads across the source-specific interfaces.

14 September 2026 · Frozen model comparisons

Published the supplied MPRA, QTL, fine-mapping, clinical and LDSC comparisons with original captions, result tables and file checksums. These figures retain the 14 September analysis samples and are separate from the earlier record-browser release.

Initial score release · 2026

6,475,578 common human variants on GRCh38, chromosomes 1–22, with scores from Evo2 7B and 40B under noRC, avgRC and wtRC strategies. The September website changes preserve the original variant identities, model scores and existing scientific annotations.